A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

S.E. de Laszlo,Eric E. Allen,Bing Li,Debra Ondeyka,Ralph A. Rivero,Lorraine Malkowitz,C J Molineaux,S J Siciliano,M S Springer,William J. Greenlee,Nathan B. Mantlo

A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

1997

S.E. de Laszlo
Eric E. Allen
Bing Li
Debra Ondeyka
Ralph A. Rivero
Lorraine Malkowitz
C J Molineaux
S J Siciliano
M S Springer
William J. Greenlee
Nathan B. Mantlo

The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.

Keywords:

Functional selectivity
Chemical synthesis
C5a receptor
Agonist
Organic chemistry
Ligand (biochemistry)
Carboxamide
Stereochemistry
Chemistry
Biochemistry
Ligand binding assay
Ligand

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