Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

Masashi Takawa,Hyun-Soo Cho,Shinya Hayami,Gouji Toyokawa,Masaharu Kogure,Yuka Yamane,Yukiko Iwai,Kazuhiro Maejima,Koji Ueda,Akiko Masuda,Naoshi Dohmae,Helen I. Field,Tatsuhiko Tsunoda,Takaaki Kobayashi,Takayuki Akasu,Masanori Sugiyama,Shin Ichi Ohnuma,Yutaka Atomi,Bruce A.J. Ponder,Yusuke Nakamura,Ryuji Hamamoto

Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression

2012

By revealing a specific mechanism of epigenetic regulation of a central cell-cycle regulator implicated in many cancers, this study establishes a lysine methylation pathway as a potential target for generalized cancer treatment.

Keywords:

Methylation
Proliferating cell nuclear antigen
Cancer research
Molecular biology
Regulator
Epigenetics
Methyltransferase
Histone-Lysine N-Methyltransferase
Histone methyltransferase
Carcinogenesis
Biology
Lysine

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

132

Citations