Preadmission predictors of severe COVID-19 in patients with diabetes mellitus.

Abstract Objective To explore predictors of severe COVID-19 disease in patients with diabetes hospitalized for COVID-19. Methods This is a retrospective observational study of adults with diabetes admitted for COVID-19. Bivariate tests and multivariable Cox regression were used to identify risk factors for severe COVID-19, defined as a composite endpoint of intensive care unit admission/intubation or in-hospital death. Results In 1134 patients with diabetes admitted for COVID-19, more severe disease was associated with older age (HR 1.02, p  Conclusions Age, male sex, Asian race, and obesity were associated with increased risk of severe COVID-19 disease in adults with type 2 diabetes hospitalized for COVID-19. Summary In patients with type 2 diabetes hospitalized for COVID-19 disease, we observed that age, male sex, Asian race, and obesity predicted severe COVID-19 outcomes of intensive care unit admission, intubation, or in-hospital death. The risk conferred by obesity increased with worsening obesity. Outpatient diabetes medications were not observed to be significant predictors of study outcomes.