Pancreatic Glucose Uptake in Vivo in Men with Newly Diagnosed Type 1 Diabetes

Context: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events that are necessary for the progression toward overt type 1 diabetes. Design: To evaluate possibilities to visualize insulitis in man in vivo with positron emission tomography, we studied 12 male patients (age 26 ± 7 yr) with newly diagnosed type 1 diabetes (duration range 0–7 months) and nine age- and sex-matched healthy controls after an overnight fast using 2-[18F]fluoro-2-deoxy-d-glucose and [11C]methionine. For definition of the regions of interest, pancreas was localized with magnetic resonance imaging or computed tomography-positron emission tomography. Results: Glucose uptake to the pancreas was markedly higher in the patients with type 1 diabetes than in the healthy controls (22.9 ± 6.4 vs. 17.8 ± 6.0 μm...