Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery

Prajakta Gadgil,Candice Alleyne,Kung-I. Feng,Mengwei Hu,Marian E. Gindy,Alexei V. Buevich,Scott E. Fauty,Gino Salituro,Jianzhong Wen,Ying Li,Rebecca Nofsinger,Tomi K. Sawyer,Nicole Buist

Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery

2019

Prajakta Gadgil
Candice Alleyne
Kung-I. Feng
Mengwei Hu
Marian E. Gindy
Alexei V. Buevich
Scott E. Fauty
Gino Salituro
Jianzhong Wen
Ying Li
Rebecca Nofsinger
Tomi K. Sawyer
Nicole Buist

Purpose In this study we evaluated the utility of in-vitro screening tools for predicting the in-vivo behavior of six cyclic peptides with different solubility and permeability properties (BCS class II and III), intended for oral delivery in presence of permeation enhancer Labrasol.

Keywords:

Biochemistry
Permeability (electromagnetism)
Permeation
Peptide
Solubility
Cyclic peptide
In vitro
Chromatography
Enhancer
Chemistry
In vivo
membrane permeability
Bioavailability

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