Mesoporous silicon nanotechnology for cancer application

Despite the significant breakthroughs in tumor detection, surgery, chemotherapy, and radiotherapy, there remains a significant need for the development of innovative approaches to decrease cancer morbidity and mortality. Nanotechnology is a multidisciplinary approach associated with physics, biology, chemistry, mathematics, and engineering, offering unprecedented opportunities to improve the current medical and clinical practice. In this article, we present the development of multistage nanovector approach for a synergistic targeting and delivery of therapeutic agents, providing disruptive technology to overcome the biological barriers that impede efficient drug delivery. We further present an integrated multifunctional nanoproteomics platformcombined with mass spectrometry for the screening and discovery of biomarkers for early diagnosis and therapy monitoring. These two nanotechnology platforms together will provide potential for development of an effective personalized medicine.