[The preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and its pharmacokinetics characters].

Investigation of the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments by the skin-blood synchronous microdialysis coupled with LC/MS is reported in this study.The microdialysis systems were established by linear probes and concentric circles probes.In vivo recovery of paeonol in skin is(69.7 ± 4.8) % and in blood is(51.6 ± 7.2) %.The paeonol microemulsion,microemulsion-based gels and marketed paeonol ointments were administered to rats.PBS(pH 7.4) served as perfused solution.The perfusion rate was 5 μL?mL?1 and the microdialysis samples were collected every 20 min intervals.The paeonol concentration in perfused solution was determined by LC/MS.The results showed that paeonol microemulsion and microemulsion-based gels significantly raised the drug concentrations in skin more than that of paeonol ointments.The paeonol microemulsion-based gels has similar bioavailability as the paeonol ointments in blood,but its blood drug concentrations were steadier.The paeonol microemulsion-based gels may be developed into a new preparation for dermis eczema.The skin-blood synchronous microdialysis technique proved to be a new method for the pharmacokinetics study of transdermal delivery systems.