Treatment patterns and comorbidities in a population-based cohort of glioblastoma patients diagnosed 1997-2008.

1591 Background: Glioblastoma multiforme (GBM) is one of the most common, most malignant and rapidly progressive forms of brain cancer. Published reports of GBM in non-trial populations are limited. The purpose of this study was to assemble a population-based cohort of GBM patients with comprehensive clinical and demographic information and to define treatment patterns and outcomes in this population. Methods: GBM patients served by Henry Ford Health System (HFHS), a major GBM referral center, were identified using ICD-O and histology codes from the HFHS tumor registry. Eligible patients were newly diagnosed with GBM between 1997 and 2008. Comprehensive, population-based data were compiled using tumor registry data (including histology and mortality) with linkages to pharmacy data (including infusion), outpatient and inpatient encounter data, and laboratory results. Results: Overall, 812 GBM patients were identified; mean age was 54 years (standard deviation 15.8). The cohort was 63% male and 84% white. A...