Influence of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in animal models

Abstract Background The objective of this study was to investigate the effect of atazanavir on the pharmacodynamics and pharmacokinetics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination. Methods Blood samples were analysed for blood glucose by GOD/POD method, serum gliclazide levels by HPLC method and insulin by Radio Immuno Assay method. Results In combination, atazanavir significantly enhanced the pharmacodynamic activity and altered the pharmacokinetic parameters of gliclazide in animal models. Conclusions The interaction between atazanavir and gliclazide appears to be pharmacokinetic interaction at metabolic level in animal models.