PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey.

Xiaoyun Zhou,Bin Ji,Chie Seki,Yuji Nagai,Takafumi Minamimoto,Masayuki Fujinaga,Ming-Rong Zhang,Takashi Saito,Takaomi C. Saido,Tetsuya Suhara,Yasuyuki Kimura,Makoto Higuchi

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey.

2021

Xiaoyun Zhou
Bin Ji
Chie Seki
Yuji Nagai
Takafumi Minamimoto
Masayuki Fujinaga
Ming-Rong Zhang
Takashi Saito
Takaomi C. Saido
Tetsuya Suhara
Yasuyuki Kimura
Makoto Higuchi

Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, 11C-GW2580, and compared it to a reported CSF1R tr...

Keywords:

pet imaging
Radioligand
Cancer research
Medicine
head to head
Biomarker (medicine)
Microglia
Receptor
Neuroinflammation
Colony stimulating factor 1 receptor

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