Multimodal CT Imaging Characteristics in Predicting Prognosis of Wake-Up Stroke

Background: Multimodal CT imaging can evaluate cerebral hemodynamics and stroke etiology, playing an important role in predicting prognosis. This study aimed to summarize the comprehensive image characteristics of wake-up stroke (WUS), and to explore its value in prognostication. Methods: WUS patients with anterior circulation large vessel occlusion were recruited into this prospective study. According to the 90-day modified Rankin Scale (mRS), all patients were divided into good outcome (mRS 0-2) or bad (mRS 3-6). Baseline clinical information, multimodal CT imaging characteristics including NECT ASPECTS, clot burden score (CBS), collateral score, volume of penumbra and infarct were compared. Logistic regression analysis was further used to analyze predictive factors for good prognosis. Area under curve (AUC) was calculated from the receiver operating characteristic (ROC) curve to assess prognostic value. Results: 40 WUS were analyzed in this study, with 20 (50%) achieving good outcome. Upon univariable analysis, the good outcome group demonstrated higher ASPECTS (9 [8-10] vs. 8 [6-9], p=0.017), higher CBS (7.35±1.57 vs. 4.00±3.56, p=0.003), higher rate of good collateral filling (85% vs. 20%, p<0.01) and lower penumbra volume (85.21±48.35 vs. 119.81±69.13, p= 0.020) when compared with the poor outcome group. Upon logistic regression analysis, poor outcome significantly correlated with penumbra volume (OR: 1.023, 95% CI=1.003-1.043) and collateral score (OR: 0.140, 95% CI=0.030-0.664). AUC was 0.715 for penumbra volume (95% CI, 0.550-0.846) and 0.825 for good collateral (95% CI, 0.672-0.927) in predicting outcome. Conclusions: Penumbra volume and collateral score are the most relevant baseline imaging characters in predicting outcome of WUS patients. Further