SYNTHESIS AND SPECTRAL CHARACTERIZATION OF 2-AZITIDINONE DERIVATIVES

Azitidinone commonly called β-lacrams and it is well known heterocyclic compound. In the present work efficient and rapid synthesis of novel β-lactams has been established in good yields starting from aromatic carbonyl and aromatic amine. The Schiff base obtain from the aromatic carbonyl compound and aromatic amine in ethyl alcohol, then in situ ketene formed from acetyl chloride and triethyl amine, then ketene and Schiff base form 2-azitidinone. After synthesis we characterize the structure of 4-thiazolidinone derivative on the basis if IR and H1 NMR. The purity of the synthesized compound was confirmed by TLC.