P2-283Simultaneous and sequential treatment of cancer with tuberculosis: Experience from a tuberculosis control unit in Japan

Abstract Background Tuberculosis (TBC) is a major public health problem with high mortality especially in developing countries. It is associated with a higher risk of developing pulmonary and non-pulmonary malignancies including solid and hematologic cancers. Association between TBC and nonpulmonary malignancies is rarely described in the literature. This study aims to determine the characteristics of patients who had been treated for cancer after they were diagnosed with TBC. Methods This is a retrospective study conducted over a period of 4 years (between 2014 and 2018), including 20 patients followed up for cancer and TBC at the TBC control unit, The Jikei Daisan Hospital, Japan. TBC and cancer were diagnosed synchronously in 13 cases. Results The average age of patients was 76 years old. The sex ratio was 0.81. The different locations of cancer were represented by the urogenital organs (5 case), the blood (4 cases), the breast (4 cases), the gaster and colon (2 case), the lung (2 cases), the pancreas (2 cases), and the tongue (1 case). Thirteen of these patients received concurrently aggressive management such as chemotherapy, surgery or hormone therapy. All patients received anti TBC treatment for at least six months. Surgery was indicated in four cases (mastectomy, gastrectomy, total orchiectomy, and nephrectomy). A complete remission of cancer was observed in these 4 patients. Concerning TBC, recovery was observed in 19 patients. Conclusion In our TBC control unit, the presence of TBC with cancer did not cause poor prognosis and untreatability of cancer in most cases. A well-planned TBC management with personalized support would provide safe and effective cancer treatment.