Fever, Anasarca and Arthralgia

Less than 1% of systemic lupus erythematosus (SLE) cases are associated with complement deficiencies Complete C1q, C1s and C1r deficiencies are associated with a high risk to of juvenile SLE Macrophage activation syndrome (MAS) is a known complication of pediatric rheumatic disorders and a secondary/reactive form of hemophagocytic lymphohistiocytosis In SLE, MAS can mimic an acute exacerbation of the underlying disease, associated with fever, lymphadenopathy, splenomegaly and cytopenia