Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes

Abstract The attachment of monocytes and lymphocytes to endothelial cells, which initiates atherosclerosis, arises under the influence of adhesion molecules. The preclinical phase of this disease lasts many decades, and this provides an opportunity for the presymptomatic detection of high-risk subjects. We evaluated levels of the adhesion molecules: sICAM-1 (soluble intercellular adhesion molecule 1), sVCAM-1 (soluble vascular adhesion molecule 1), sE selectin, sP selectin, and sL selectin in children with atherosclerosis risk factors (n = 123, mean age 15.1 years) (obese [n = 17], hypertensive [n = 25], obese with hypertension [n = 30], type 1 diabetic [n = 51]). Twenty-seven healthy children formed the control group, mean age 15.2 years. sICAM-1 was higher in the study group compared with control (314.1 ± 61 vs 264.9 ± 55 ng/mL, P P P r = 0.18, P = .03), total cholesterol ( r = 0.2, P = .016), and triglycerides ( r = 0.22, P = .008). sICAM-1 correlated with BMI ( r = 0.19, P = .019) and systolic blood pressure ( r = 0.13, P = .045). In multiple linear regression analysis, sE selectin was found to be associated with triglycerides ( R 2 = 0.29, P = .045), sICAM-1 dependent on BMI (R 2 = 0.58, P = .047), and sVCAM-1 dependent on total cholesterol ( R 2 = 0.51, P = .006). Elevated concentrations of sICAM-1, sVCAM-1, and E selectin were found in obese, hypertensive, and diabetic children. We conclude that endothelial activation appears in these children, and adhesion molecules are related to the earliest stages of atherosclerosis.