EVALUATION OF MARKERS OF OXIDATIVE STRESS AND INFLAMMATTION IN PATIENTS WITH END-STAGE KIDNEY DISEASES

End-stage kidney diseases (ESKD) represent terminal stage of chronic kidney diseases (CKD) and they have common elements that can be interlinked through the pathways regulated by oxidative stress and chronic inflammation. Therefore the aim of our study was to determine the markers of oxidative damage to DNA, proteins and lipids, also the levels of antioxidant defence (SOD, CAT, and GPx) and special markers (neopterin, paraoxonase activity, ADMA) which are associated with cardiovascular diseases in patients in ESKD undergoing haemodialysis approximately for 3.5 years (2–6.5 years). The study involved 27 outpatients (9 female and 18 male) with CKD (average age 62.9±1.76 years) based on primary diagnoses divided into four groups: chronic tubulointerstitial nephritis (ChTIN), glomerulonephritis (ChGN), polycystic kidneys (PK) and diabetic nephropathy (DN). Our results confirmed elevated levels of markers of inflammation and oxidative damage in all groups compared to healthy volunteers. The parameters also confirmed the different participation of oxidative stress in pathophysiology of ESKD.