Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

Jianan Sun,Yang Gui,Yekai Huang,Jindong Li,Zhenggen Zha,Yu Yang,Zhiyong Wang

Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

2020

Jianan Sun
Yang Gui
Yekai Huang
Jindong Li
Zhenggen Zha
Yu Yang
Zhiyong Wang

Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation pr...

Keywords:

Alkylation
Organic chemistry
Enantioselective synthesis
Catalysis
Friedel–Crafts reaction
Lewis acids and bases
Pyrrole
Chloroform
Chemistry

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