Steric and Chelate Ring Size Effects on the Enantioselectivity in Palladium-Catalyzed Allylic Alkylation with New Chiral P,N-Ligands.

Abstract New chiral P,N-ligands derived from substituted pyridine and (S)-2,2′-binaphthol phosphorochloridite have been prepared and tested in asymmetric palladium-catalyzed allylic alkylations. The enantioselectivity was poorly dependent on the pyridine substituent, instead, a chelate ring size effect was apparent.