METHYLENE ACETALS AS PROTECTING GROUPS : AN IMPROVED PREPARATION METHOD

Abstract A facile method to protect vic diols, 1,3 diols and other hydroxyl functions as methylene acetals is achieved by treating the relative substrates with POCl 3 or SOCl 2 in DMSO. The good yields obtained, the good solubility of many organic compounds in DMSO and the easy hydrolysis of the 1,3,5-trioxaepane derivatives prepared from trans vic diols make useful this protecting method.