The study of klebsiella releasing endotoxin induced by antibiotics in vitro

OBJECTIVETo study the potential of different antibiotics used independently or in combination in different concentrations in the inducement of endotoxin released by bacteria. For rational use of antibiotics. METHODSSelect 9 types of antibiotics in the concentions of 1 time MIC,10 times MIC,100 times MIC acting independently to the sensible klebsiella. The amount of bacteria endotoxin released after four hours applying each antibiotics is measured. RESULTSThe least amount of endotoxin released is induced by the antibiotics of which acting independently or in combination is Aminoglycosides, the next is F-Quinolones,then is lactamase inhibitors. The lower concentration of antibiotic the more bacteria endotoxin released.CONCLUSIONIt is reasonable to choose abtubuitucs with considering the characteristic of the endotoxin release by bacteria.