Effect of oleanolic acid on the regulation of water, electrolyte and the renin system (701.4)

Effect of oleanolic acid on the regulation of water, electrolyte and the renin system Yoon Hee Choi1,2, Min Chul Kho1,2, Ji Hun Park2,3, Kyung Woo Cho1,2, Dae Gill Kang1,2,3, Ho Sub Lee1,2 1Professional graduate school of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea 2 Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Republic of Korea 3Department of Food Industry Convergence, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea ABSTRACT Oleanolic acid is an active ingredient of variable plants including medicinal herbs and edible vegetables. Previously, it was shown that oral intake of oleanolic acid accentuates the atrial natriuretic peptide (ANP) system. Oleanolic acid increases cardiac ANP synthesis, plasma levels, and secretion. The purpose of the present study was to identify the effects of oleanolic acid on the regulation of fluid and electrolyte homeostasis and renal hormone balance. Experiments were perf...