Identification of Hypertension Susceptibility Loci on Rat Chromosome 12

Previous studies have identified multiple blood pressure and renal disease quantitative trait loci located on rat chromosome 12. In the present study, we narrowed blood pressure loci using a series of overlapping Dahl salt-sensitive/Mcwi (SS)-12 Brown Norway (BN) congenic lines. We found that transferring 6.1 Mb of SS chromosome 12 (13.4–19.5 Mb) onto the consomic SS-12 BN background significantly elevated blood pressure on 1% NaCl (146 ± 6 versus 127 ± 1 mm Hg; P P BN consomic, these animals also had significantly elevated albumin (218 ± 31 versus 104 ± 8 mg/d; P P