Specific antibody for EPHB3 and uses thereof

A monoclonal antibody that (a) binds to the extracellular domain of EphB3 with an affinity (KD) of 10-6 M atoms, (b) (i) competes with antibody XPA.04.001, which comprises a variable region of the light chain of SEQ ID NO: 3 and a variable region of the heavy chain of SEQ ID NO: 4 to bind to EphB3 more than 75%, (ii) competes with the antibody XPA.04.013, which comprises a variable region of the light chain of SEC ID NO: 5 and a variable region of the heavy chain of SEQ ID NO: 6 to bind to EphB3 more than 75%, (iii) competes with the XPA.04.018 antibody, which comprises a variable region of the light chain of SEQ ID NO: 7 and a variable region of the heavy chain of SEQ ID NO: 8 to bind to EphB3 more than 75%, (iv) competes with the antibody XPA.04.048, which comprises a variable region of the light chain of SEQ ID NO: 9 and a heavy chain variable region of SEQ ID NO: 10 to bind to EphB3 more than 75%, (v) comprises the 6 CDRs of antibody XPA.04.0 01 (residues 24-39 (CDR1), 55-61 (CDR2) and 94-102 (CDR3) of SEQ ID NO: 3 and residues 26-35 (CDR1), 50-66 (CDR2) and 99-102 ( CDR3) of SEQ ID NO: 4), (vi) comprises the 6 CDRs of antibody XPA.04.013 (residues 24-39 (CDR1), 55-61 (CDR2) and 94-102 (CDR3) of SEQ ID NO: 5 and residues 26-35 (CDR1), 50-66 (CDR2) and 99-103 (CDR3) of SEQ ID NO: 6), (vii) comprises the 6 CDRs of antibody XPA.04.018 (residues 24-39 (CDR1) ), 55-61 (CDR2) and 94-102 (CDR3) of SEQ ID NO: 7 and residues 26-35 (CDR1), 50-66 (CDR2) and 99-102 (CDR3) of SEQ ID NO: 8 ), or (viii) comprises the 6 CDRs of antibody XPA.04.048 (residues 24-39 (CDR1), 55-61 (CDR2) and 94-102 (CDR3) of SEQ ID NO: 9 and residues 26-35 ( CDR1), 50-66 (CDR2) and 99-102 (CDR3) of SEQ ID NO: 10), and (c) induces phosphorylation of EphB3 and / or degradation of EphB3.