155-OR: Diabetes Complications and Cognitive Function in Youth with Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Both type 1 (T1D) and type 2 diabetes (T2D) impart significant risk for cognitive dysfunction. Adults experiencing diabetes-related complications in particular, have pronounced cognitive deficits. It is unknown whether multiple diabetes complications co-occur with cognitive dysfunction, specifically in youth-onset T1D and T2D. Using data from the SEARCH for Diabetes in Youth cohort study, we examined clustering of diabetes type, complications, and performance on cognitive tests in young adults with youth-onset T1D or T2D. Cognition was assessed via the NIH Toolbox Cognition Battery and age-corrected scores for composite fluid cognition were used. Diabetes complications included retinopathy, microalbuminuria, arterial stiffness, peripheral neuropathy, and cardiac autonomic neuropathy (CAN). Hierarchical clustering was applied with 795 participants (T1D=635; T2D=160). Three clusters emerged. Cluster 1 (C1; n=154) had the lowest composite fluid cognition scores, compared with Clusters 2 (C2; n=603) and 3 (C3; n=38) (mean [SD] 84.3 [17.7], 96.9 [15.7], 97.3 [16.2]; p Disclosure A. Shapiro: None. S. M. Marcovina: None. A. D. Liese: None. A. K. Mottl: Advisory Panel; Self; Bayer U. S. E. T. Jensen: None. G. Wilkening: None. A. Bellatorre: None. D. Dabelea: None. J. M. Stafford: None. R. Dagostino: Consultant; Self; AstraZeneca, Biogen, Daiichi Sankyo. A. S. Shah: None. E. M. Urbina: None. C. E. Barrett: None. C. Pihoker: None. Funding Centers for Disease Control and Prevention (00097, DP-05-069, DP-10-001, 1U18DP006131, U18DP006133, U18DP006134, U18DP006136, U18DP006138, U18DP006139); National Institute of Diabetes and Digestive and Kidney Diseases (1UC4DK108173); Kaiser Permanente Southern California (U18DP006133, U48/CCU919219, U01DP000246, U18DP002714); University of Colorado Denver (U18DP006139, U48/CCU819241-3, U01DP000247, U18DP000247-06A1); Cincinnati’s Children’s Hospital Medical Center (U18DP006134, U48/CCU519239, U01DP000248, 1U18DP002709); University of North Carolina at Chapel Hill (U18DP006138, U48/CCU419249, U01DP000254, U18DP002708); Seattle Children’s Hospital (U18DP006136, U58/CCU019235-4, U01DP000244, U18DP002710-01); Wake Forest University School of Medicine (U18DP006131, U48/CCU919219, U01DP000250, 200-2010-35171)