Synthesis and structural study of new substituted chiral sulfamoyl oxazolidin-2-ones

The synthesis of new series of oxazolidinones having sulfonamide moieties is described. These compounds are synthesized in good yield starting prochiral 1,3-dichloro-2-propanol and chlorosulfonyl isocyanate. This strategy involves the formation of carboxylsulfamide by carbamoylation–sulfamoylation reaction followed by intermolecular cyclization. In order to determine the enantioselectivity during the cyclization step, X-ray studies of products are performed.