Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.

Brendan M. Gabriel,Ali Altıntaş,Jonathon A. B. Smith,Laura Sardón Puig,Xiping Zhang,Astrid L. Basse,Rhianna C. Laker,Hui Gao,Zhengye Liu,Lucile Dollet,Jonas T. Treebak,Antonio Zorzano,Zhiguang Huo,Mikael Rydén,Johanna T. Lanner,Karyn A. Esser,Romain Barrès,Nicolas J. Pillon,Anna Krook,Juleen R. Zierath

Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.

2021

Circadian rhythms are generated by an autoregulatory feedback loop of transcriptional activators and repressors. Circadian rhythm disruption contributes to type 2 diabetes (T2D) pathogenesis. We el...

Keywords:

Neuroscience
Metabolism
Pathogenesis
Skeletal muscle
Biology
Type 2 diabetes
Rhythm
Circadian rhythm

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