Ethological Effect of Yizhi-Fangdai decoction on model mice with learning and memory impairment

Objective To observe the ethological effect of Yizhi-Fangdai decoction on model mice with learning and memory impairment.Methods According to literature method to establish model mice with memory acquirement disorder by scopolamine,memory consolidation disorder by sodium nitrite and memory retrieval disorder by ethyl alcohol.Each model mice were randomly divided into normal group,model group,donepezil group and different doses of Yizhi-Fangdai decoction group.Each group received the appropriate intervention measures.Then,jump platform experiment,water directly maze experiment and step-through experiment were tested after 7day's intragastric administration,and the latency stage and number of errors were recorded.Results Compared with model group,the latency stage of different doses of Yizhi-Fangdai decoction intervention group was significantly prolonged(P0.01)and the number of errors was significantly decreased(P0.01)among memory acquirement disorder model mice.Compared with model group, the swimming time of different doses of Yizhi-Fangdai decoction intervention group was significantly prolonged( P0.05) and the number of errors was significantly decreased( P0. 05) among memory consolidation disorder model mice; Compared with model group, the latency stage of different doses of Yizhi-Fangdai decoction intervention group was significantly prolonged( P0.05) and the number of errors was significantly decreased( P0.05) among memory retrieval disorder model mice.Conclusions Yizhi-Fangdai decoction can improve the ability of memory acquirement, memory consolidation and memory retrieval in model mice with learning and memory dysfunctions, and it can promote learning and memorial function at different stages of learning and memory.