Platelet activation in normo- and hyperlipoproteinemias

In the last few years it became obvious that platelets are involved in the development of atherosclerotic diseases. This involvement of platelets has been taken into account in the “response to injury” hypothesis of atherosclerosis. The hypothesis is based on the assumption that atherosclerotic lesions result from endothelial injury, followed by the interaction of, vessel wall constituents with lipoproteins, macrophages, and platelets.