Intravenous Valproate in Status Epilepticus

OBJECTIVE:To evaluate the role of intravenous valproate sodium (IV VPA) in the treatment of status epilepticus (SE).DATA SOURCES:A literature search of the English language was performed (MEDLINE 1966–July 2000). Search terms included valproate, valproic acid, and status epilepticus. Bibliographies of articles chosen were reviewed to identify other possible sources.DATA SYNTHESIS:A review of the medical literature was conducted to evaluate the safety and efficacy of IV VPA in the treatment of SE.CONCLUSIONS:Experience with IV VPA in the treatment of SE is too limited to recommend its use as a first-line agent. IV VPA may represent a third- or fourth-line option in cases of SE when other agents are ineffective or contraindicated.