Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
2021
This work was supported by grants from Gobierno Vasco-Departamento de Salud
2013111114 (to M.L.M.-C), ELKARTEK 2016, Departamento de Industria del
Gobierno Vasco (to M.L.M C), Ministerio de Ciencia, Innovacion y Universidades
MICINN: SAF2017-87301-R, and RTI2018-096759-A-100 integrado en el Plan
Estatal de Investigacion Cientifica y Tecnica y Innovacion, cofinanciado con Fondos
FEDER (to M.L.M T.C.D respectively); MCIU/AEI/FEDER, UE (RTI2018-095134-B-
100) (to P.A.), AECC Bizkaia (M.S-M); Asociacion Espanola contra el Cancer (T.C.D),
Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AECC Scientific
Foundation) Rare Tumor Calls 2017 (to M.L.M, J.M.B., M.A.A., J.J.G.M.), La Caixa
Foundation Program (to M.L.M and J.M.B.), 2018 BBVA Foundation Grants for
Scientific Research Teams (to M.L.M.-C.), Ayudas para apoyar grupos de investigacion
del sistema Universitario Vasco IT971-16 (P.A.). MyFirst Grant AIRC
n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca
corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (to LV), the
European Union (EU) Programme Horizon 2020 (under grant agreement No.
777377) for the project LITMUS- “Liver Investigation: Testing Marker Utility in
Steatohepatitis” (to LV), Fondazione IRCCS Ca’ Granda “Liver BIBLE” PR-0391,
Fondazione IRCCS Ca’ Granda core COVID-19 Biobank (RC100017A) (to LV). This
research was funded by the CIBERehd (EHD15PI05/2016) and “Fondo de Investigaciones
Sanitarias, Instituto de Salud Carlos III”, Spain (PI16/00598 and PI19/
00819, co-funded by European Regional Development Fund/European Social Fund,
“Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness
(SAF2016-75197-R); “Junta de Castilla y Leon” (SA063P17); AECC Scientific
Foundation (2017/2020), Spain; “Centro Internacional sobre el
Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain; University of Salamanca
Foundation, Spain (PC-TCUE18-20_051), and Fundacio Marato TV3
(Ref. 201916e31), Spain. RB acknowledges BFU2017-84653-P (MINECO/FEDER,
EU), SEV-2016-0644 (Severo Ochoa Excellence Program), 765445-EU (UbiCODE
Program), SAF2017-90900-REDT (UBIRed Program), and IT1165-19 (Basque
Country Government). Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud
Carlos III. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC
bioGUNE (SEV-2016-0644). Finally, we would like to acknowledge Begona Rodriguez
Iruretagoyena for the technical support provided.
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