To determine the diagnostic accuracy of optical coherence tomography in the early detection of choroidal neovascularisation in patients with age related macular degeneration taking fluorescein angiography as gold standard.

AIM: To determine the diagnostic accuracy of optical coherence tomography (OCT) with fundus fluorescein angiography (FA) in the early detection of choroidal neovessels (CNV) in patients with age related macular degeneration (AMD) taking FA as gold standard. MATERIALS AND METHODS: This cross-sectional study was conducted at Eye Unit III, Institute of Ophthalmology, King Edward Medical University / Mayo Hospital, Lahore. 205 patients were studied for early detection of CNV in patients with AMD by determining the diagnostic accuracy of OCT with FA. RESULTS: Out of 205 cases, 45.37% (n=93) were between 50-65 years of age and 54.63% (n=112) were between 66-80 years of age, mean ± SD was calculated as 65.52 ± 6.93, 57.56% (n=118) were male and 42.44% (n=87) were females. Frequency of CNV on FA was recorded in 38.54% (n=79). Diagnostic accuracy of OCT vs FA in the early detection of CNV in patients with AMD taking FA as gold standard was calculated which shows sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate as 89%, 73.02%, 67.62%, 92% and 79.51% respectively. CONCLUSION: This concluded a higher diagnostic accuracy of OCT vs FA in the early detection of CNV in patients with AMD. KEYWORDS: Age Related Macular Degeneration, Choroidal Neovascularization, Optical Coherence Tomography.