Activation of human prothrombin by porcine aortic endothelial cells—a potential barrier to pig to human xenotransplantation

A potential solution to the shortage of human organs for transplantation lies in the use of animal organs with the pig as the most likely donor. Perfusion of porcine organs with human blood, however, results in hyperacute rejection (xenograft reaction) which occurs within minutes to hours and is cha