Treatment of experimental cytomegalovirus infections with acyclovir

Subcutaneous (s.c.) administration of Acyclovir (ACV) (100 mg/1 kg bodyweight) resulted in an ACV blood level of 80 µM at 2 h post infection. Thereafter the level declined rapidly reaching undetectable levels at 12 h post infection. Administration of pro-ACV (100 mg/kg body weight) by s.c. or intravenous (i.v.) route resulted in ACV levels of 75 µM and 160 µM respectively after 30 min. But here again the blood level of ACV declined rapidly and was completely disappeared after 12 h.