[Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS].

Objective: To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts.Method: The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS.Different peaks were observed in total ion chromatograms and then identified according to their retention time,accurate mass weight,MS and MS/MS data.Result: After oral administration of Chuanxiong Rhizoma extracts,3 compounds were absorbed into rat brain tissues through BBB.They were identified as senkyunolide I,senkyunolide A and ligustilide.Conclusion: The study is helpful for interpreting effective substance of Ligusticum chuanxiong.