Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Piyusha P. Pagare,Aref Rastegar,Osheiza Abdulmalik,Abdelsattar M. Omar,Yan Zhang,Andrew Fleischman,Martin K. Safo

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

2021

Piyusha P. Pagare
Aref Rastegar
Osheiza Abdulmalik
Abdelsattar M. Omar
Yan Zhang
Andrew Fleischman
Martin K. Safo

Sickle cell disease (SCD) is a debilitating inherited disorder that affects millions worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin (Hb) modulator Voxelotor.Thi...

Keywords:

Pharmacology
oxygen affinity
Disease
Allosteric regulation
Hemoglobin
Cell
Medicine

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