Clinical significance of specific features of HLA antigen incidence in patients with mucoviscidosis and in their relatives

The distribution of antigens in the HLA system was studied in 57 patients with mucoviscidosis and in their 43 relatives. The examinees were found to have increased incidence of the HLA antigens B40, CW2, CW3, CW4. The haplotype AIB40 was associated with the mutation carriage of the CF gene deletion F508 both in patients and their relations heterozygous for this mutation. The analysis of the level of HLA antigens in the tissue of CF patients may predict the development of particular clinical features of mucoviscidosis and the nature of the course of the disease.