Stimulatory effects of fibronectin and EGF on migration of corneal epithelial cells.

The effects of fibronectin and epidermal growth factor (EGF) on the migration of corneal epithelial cellsin situ were investigated. When rabbit corneal blocks were cultured in serum-free medium with fibronectinor EGF, corneal epithelial cells migrated on the cut surface of the stroma. Histological and electronmicroscopic studies revealed that the leading edge of the fibronectin-treated cornea was thin, single-layered epithelium, whereas the leading edge of the EGF-treated cornea was a hypertrophic, multilayeredepithelium. By autoradiography wit