Study of nimesulide and its determination using multiwalled carbon nanotubes modified glassy carbon electrodes

Abstract A new method for the determination of nimesulide was established based on the multiwalled carbon nanotubes (MWCNTs) modified glassy carbon electrode (MWCNTs/GCE). In 0.2 M PBS (pH 6.6) buffer solution, the MWCNTs/GCE showed a remarkable catalytic and enhancement effect on reduction of the nimesulide. The reduction peak potential of nimesulide shifted positively from −0.665 V at bare GCE to −0.553 V at MWCNTs/GCE, and the sensitivity increased ca. 7 times. A linear dynamic range of 3.2 × 10 −7 –6.5 × 10 −5  M ( R  = 0.9992) with a detection limit of 1.6 × 10 −7  M was obtained. The electrochemical behaviors of nimesulide were studied and electron-transfer coefficient ( α  = 0.45), proton number ( X  = 1) and electron-transfer number ( n  = 2) have been determined. This method has been used to determine the content of nimesulide in medical tablets. The recovery was determined to be 93.2–106.2% by means of standard addition method. Compared with UV–vis spectrometry, the method was not remarkable difference.