Crystallization method of rosuvastatin calcium intermediate

The invention discloses a crystallization method of a rosuvastatin calcium intermediate. The crystallization method comprises the following steps: (1) adding the prepared grease of an intermediate H3 to a mixed solvent composed of an ester solvent, an alkane solvent and an ether solvent, performing primary pulping and evaporating out one part of the mixed solvent under reduced pressure; (2) adding the ether solvent and performing secondary pulping; (3) adding the alkane solvent; (4) adding the seed crystal of the intermediate H3; and (5) adding the ether solvent, performing third pulping, and separating out solid to obtain the solid product of the intermediate H3. According to the crystallization method of the rosuvastatin calcium intermediate, the mixed solvent is adopted to crystallization step by step so as to guarantee smooth separation of the rosuvastatin calcium intermediate H3 in the solid form and the obtained intermediate H3 is high in purity; and meanwhile, the operating method is simple, good in repeatability and suitable for industrial production.