Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

Laura Mediani,Jordina Guillén-Boixet,Simon Alberti,Serena Carra

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

2019

Laura Mediani
Jordina Guillén-Boixet
Simon Alberti
Serena Carra

ABSTRACTWe uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their ...

Keywords:

Protein folding
Nucleolus
Cell biology
Nuclear protein
Chemistry
Promyelocytic leukemia protein
Compartmentalization (psychology)
Protein quality
Organelle
Genome instability

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