Research progress of uncoupling protein 2 in pathophysiology of sepsis

Uncoupling protein 2(UCP2) is a proton transporter which presents in the mitochondrial inner membrane.Recently studies found that UCP2 plays important roles in regulation of reactive oxygen species production, maintenance of mitochondrial function, as well as inflammation and blood glucose control.These features have important relevance with the pathophysiologic mechanism of sepsis. Key words: Sepsis; Uncoupling protein 2; Pathophysiology; Mitochondria; Research progress