Metabolism of drugs. III. Genetic factors inducing and inhibiting metabolism

: In this review, a role of influence of some genetic factors on drug metabolism in liver was presented. The drug induction and inhibition of CYP enzymes whose activity is strictly genetically determined (slow and fast metabolizers), were extensively discussed. The influence of age (activity of microsomal enzymes in pediatric patients) and of food components (grapefruit juice inducing CYP enzymes) was also presented in this paper.