Primary nasal type NK/T cell lymphoma of the endometrium : A case report

Non-Hodgkin lymphoma can involve the female genital tract usually as a manifestation of systemic disease, the vast majority of cases being B cell lineage. We report here one case of nasal type NK/T cell lymphoma arising in the uterus, of a 45-year-old Korean woman. The endometrium and myometrium showed diffuse infiltrative mass with hemorrhage and necrosis. Microscopic examination of the tumor revealed medium-sized atypical lymphoid cells. The tumor cells were positive for cytoplasmic CD3 and CD56, and were negative for vimentin, CD10, smooth muscle actin and desmin. Furthermore, In situ hybridization analysis for Epstein-Barr virus (EBV) RNA was positive. The histopathologic and immunohistochemical findings were consistent with extranodal nasal type NK/T cell lymphoma. We report this case to illustrate that NK/T cell lymphomas can involve, and rarely arise in, the gynecologic tract.