Development in research on triggering receptor expressed on myeloid cells-1 signal transduction

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified molecule involved in the cascade amplification of inflammatory response.Several microbial components can up-regulate the surface expression of TREM-1 and synergizes with the ligand of TREM-1 in activating this receptor.Activation via TREM-1 induces production of pro-inflammatory cytokices and related inflammatory responses because TREM-1 can noticeably amplify the inflammatory response in endotoxemia arisen from lipopolysaccharide (LPS).There are lots of investigations about the TREM-1 activation signal pathway that have been done and have shown some progress.Otherwise,TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by LPS,but the specific mechanism is not clear enough.In this review,we will focus on the mechanism of TREM-1 signal transduction,clarifying the function of some relative signal moleculars such as TLR,DAP-12,MAPKs,NTAL,CARD9,NLRs.TREM-1 signal transduction mechanism in-depth study will further clarify the pathogenesis of sepsis and to find new therapeutic targets. Key words: Triggering receptor expressed on myeloid cells-1 (TREM-1) ;  Inflammation;  Signal transduction