Metastatic melanoma presenting during childhood: NCI Pediatric Oncology Branch experience.

10075 Background: Childhood melanoma is rare with an incidence of ~300 cases/yr in the United States. Stage IV disease is detected in 1-10% of reported pediatric melanomas. The treatment of this chemoresistant disease in pediatric patients can be quite challenging, even with access to recently approved therapies for melanoma. Limited numbers have made it difficult to determine if the presentation and characteristics of pediatric metastatic melanoma are similar to the disease seen in adults. Methods: In a retrospective chart review, we identified sixteen pediatric patients with metastatic melanoma who were referred to the Pediatric Oncology Branch. Molecular status of tumors was determined by CLIA certified tests. Patient overall survival data was collected while patients were treated with ongoing immunotherapy protocols or with treatment using approved agents. Results: A total of 16 patients aged 2-21yo were evaluated from January 2009 to January 2014. Fifteen patients had cutaneous melanoma and one teen ...