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New crystal form of agomelatine

2014 
The invention discloses a new crystal form of agomelatine. The X-ray diffraction spectrum (XRPD) of the crystal form has diffraction peaks at 2 theta angles of 11.86 +/-0.2, 17.59 +/- 0.2, 18.39 +/- 0.2, 19.71 +/- 0.2, 20.49 +/- 0.2, 21.87 +/- 0.2, 22.60 +/- 0.2, 22.97 +/- 0.2, 23.97 +/- 0.2, 24.58 +/- 0.2, 25.34 +/- 0.2, 27.12 +/- 0.2, 29.80 +/- 0.2, 30.30 +/- 0.2, 31.30 +/- 0.2, 31.98 +/- 0.2 and 40.55 +/- 0.2. The new crystal form of agomelatine disclosed by the invention is simple to prepare, good in reproducibility and good in fluidity, and the bulk density is greatly improved.
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