Adenosine receptor blockade with ciforadenant +/- atezolizumab in advanced metastatic castration-resistant prostate cancer (mCRPC).

Lauren C. Harshman,Michael Chu,Saby George,Brett G. M. Hughes,Bradley Curtis Carthon,Lawrence Fong,Jaime R. Merchan,Long Kwei,Andrew Hotson,Mehrdad Mobasher,Richard A. Miller

Adenosine receptor blockade with ciforadenant +/- atezolizumab in advanced metastatic castration-resistant prostate cancer (mCRPC).

2020

Lauren C. Harshman
Michael Chu
Saby George
Brett G. M. Hughes
Bradley Curtis Carthon
Lawrence Fong
Jaime R. Merchan
Long Kwei
Andrew Hotson
Mehrdad Mobasher
Richard A. Miller

129Background: Adenosine, generated by the ectonucleotidase CD73, mediates immunosuppression within the tumor microenvironment by triggering adenosine 2A receptors (A2AR) on immune cells. Tumor CD7...

Keywords:

Prostate cancer
Atezolizumab
Pathology
Cancer research
Tumor microenvironment
Immunosuppression
Immune system
Adenosine
Adenosine receptor
Medicine
Ectonucleotidase

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