Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.

Huize Pan,Chenyi Xue,Benjamin J. Auerbach,Jiaxin Fan,Alexander C. Bashore,Jian Cui,Dina Y. Yang,Sarah B. Trignano,Wen Liu,Jianting Shi,Chinyere O. Ihuegbu,Erin C. Bush,Jeremy Worley,Lukas Vlahos,Pasquale Laise,Robert A. Solomon,Edward S. Connolly,Andrea Califano,Peter A. Sims,Hanrui Zhang,Mingyao Li,Muredach P. Reilly

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.

2020

Background: Smooth muscle cells (SMC) play significant roles in atherosclerosis via phenotypic switching, a pathological process in which SMC dedifferentiation, migration and transdifferentiation i...

Keywords:

cell state
Cell
Cell biology
Transdifferentiation
Phenotypic switching
smooth muscle
Medicine
Genomics

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