Abstract P278: Effects of the Optimal Macro-Nutrient Intake to Prevent Heart Disease (OmniHeart) diets on urinary excretion profiles

Background: OmniHeart diets are diets rich in fruit, vegetables, and low-fat diary food with varying amount of carbohydrate, protein and unsaturated fat. These diets have been shown to reduce blood pressure, low-density lipoprotein cholesterol and coronary heart disease risk. However, the biological mechanism for this is unclear. Objective: The aim of this study is to evaluate the effects of OmniHeart diets on the urinary profiles by proton nuclear magnetic resonance (1H NMR). Methods: 158 men and women, aged 30 years and older, with prehypertension or stage 1 hypertension, each consumed three different OmniHeart diets for six weeks: a carbohydrate-rich diet (Carb, similar to the Dietary Approaches to Stop Hypertension, DASH diet); a protein-rich diet with protein predominantly from plant sources (Prot); and an unsaturated fat-rich diet mainly using monounsaturated fat (Unsat). All participants provided urine specimens at baseline (on a typical ‘American’ diet), and at the end of each dietary intervention...