Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

Ayuna Hattori,Makoto Tsunoda,Takaaki Konuma,Masayuki Kobayashi,Tamas Nagy,John Glushka,Fariba Tayyari,Daniel Ian McSkimming,Natarajan Kannan,Arinobu Tojo,Arthur S. Edison,Takahiro Ito

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

2017

Ayuna Hattori
Makoto Tsunoda
Takaaki Konuma
Masayuki Kobayashi
Tamas Nagy
John Glushka
Fariba Tayyari
Daniel Ian McSkimming
Natarajan Kannan
Arinobu Tojo
Arthur S. Edison
Takahiro Ito

BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for disease progression in chronic myeloid leukaemia.

Keywords:

Metabolism
Myeloid
Amino acid
Cancer
Immunology
Biology
Cellular differentiation
Myeloid leukemia
Gene knockdown
RNA-binding protein
Gene expression
Musashi2
Cancer research
Downregulation and upregulation

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